Спирамид

Спирамид
Систематско (IUPAC)
	8-[3-(4-Флуорофенокси)пропил]-1-фенил-1,3,8-триазаспиро[4,5]декан-4-он
Назнака
CAS-број	510-74-7
ATC код	None
IUPHAR/BPS	175
ChemSpider	61493
UNII	471LF4O004
ChEBI	CHEBI:64207
Хемиски податоци
Формула	C22H27FN3O2
Моларна маса	384,48 g·mol−1
	SMILES c2cc(F)ccc2OCCCN3CCC1(CC3)N(CNC1=O)c4ccccc4 ;
	InChI InChI=1S/C22H26FN3O2/c23-18-7-9-20(10-8-18)28-16-4-13-25-14-11-22(12-15-25)21(27)24-17-26(22)19-5-2-1-3-6-19/h1-3,5-10H,4,11-17H2,(H,24,27) ; Key:FJUKDAZEABGEIH-UHFFFAOYSA-N ;
(провери)

Спирамидот (развојно неговото кодно име е AMI-193 ) тој е експериментален антипсихотик кој делува како селективен антагонист на рецепторот на 5-HT_2A, 5-HT_1A и D ₂. Има незначителен афинитет за 5-HT _2C рецепторот.^[1]^[2]^[3]

Наводи уреди

↑ „Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist, in the squirrel monkey“. Pharmacology Biochemistry and Behavior. 67 (2): 257–64. October 2000. doi:10.1016/S0091-3057(00)00321-X. PMID 11124389.
↑ „A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone“. Progress in Neuro-psychopharmacology & Biological Psychiatry. 28 (7): 1117–27. November 2004. doi:10.1016/j.pnpbp.2004.05.046. PMID 15610924.
↑ „Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice“. Journal of Pharmacological Sciences. 105 (3): 240–50. November 2007. doi:10.1254/jphs.FP0071049. PMID 17965538.

[pmid11124389-1] „Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist, in the squirrel monkey“. Pharmacology Biochemistry and Behavior. 67 (2): 257–64. October 2000. doi:10.1016/S0091-3057(00)00321-X. PMID 11124389.

[pmid15610924-2] „A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone“. Progress in Neuro-psychopharmacology & Biological Psychiatry. 28 (7): 1117–27. November 2004. doi:10.1016/j.pnpbp.2004.05.046. PMID 15610924.

[pmid17965538-3] „Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice“. Journal of Pharmacological Sciences. 105 (3): 240–50. November 2007. doi:10.1254/jphs.FP0071049. PMID 17965538.

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