Калцитонин

Калцитонин
Расположливи структури
PDB	Пребарување во Ortholog: PDBe RCSB
List of PDB id codes
	2JXZ,%%s1LS7
Назнаки
Алијаси	CALCA, CT, CGRP-I, CGRP-alpha, KC, PCT, calcitonin related polypeptide alpha, CGRP, CGRP1, CALC1
Надворешни назнаки	OMIM: 114130 MGI: 2151253 HomoloGene: 88401 GeneCards: CALCA
Место на генот (човечки)
Хр.	Chromosome 11 (human)
Крај	14,972,351 bp
Место на генот (глушец)
Хр.	Chromosome 7 (mouse)
Крај	114,235,592 bp
Шема на РНК-експресија
	Top expressed in
	spinal ganglia; ; trigeminal ganglion; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; cerebellar vermis; ; human kidney; ; Epithelium of choroid plexus; ; tibialis anterior muscle; ; right lobe of liver;
	Top expressed in
	facial motor nucleus; ; motor neuron; ; lumbar spinal ganglion; ; anterior horn of spinal cord; ; lactiferous gland; ; trigeminal ganglion; ; vestibular membrane of cochlear duct;
	More reference expression data
	; ; ; ;
	More reference expression data
Генска онтологија
Молекулска функција	hormone activity; calcitonin receptor binding; protein binding; identical protein binding; signaling receptor binding; protein-containing complex binding;
Клеточна составница	Цитоплазма; intracellular anatomical structure; extracellular region; живчено влакно; terminal bouton; soma; neuron projection; клеточно јадро; extracellular space;
Биолошки процес	cellular response to nerve growth factor stimulus; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; negative regulation of smooth muscle contraction; regulation of heart contraction; monocyte chemotaxis; negative regulation of blood pressure; positive regulation of cytosolic calcium ion concentration; cellular response to tumor necrosis factor; стареење; вазодилатација; cellular calcium ion homeostasis; response to heat; negative regulation of nervous system process; positive regulation of ossification; activation of adenylate cyclase activity; regulation of heart rate; detection of temperature stimulus involved in sensory perception of pain; negative regulation of ossification; response to pain; artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; прехранбено поведение; inflammatory response; neuropeptide signaling pathway; negative regulation of transcription, DNA-templated; activation of protein kinase activity; embryo implantation; negative regulation of bone resorption; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of cytosolic calcium ion concentration; leukocyte cell-cell adhesion; G protein-coupled receptor internalization; positive regulation of interleukin-1 alpha production; response to yeast; negative regulation of osteoclast differentiation; cell-cell signaling; antibacterial humoral response; positive regulation of macrophage differentiation; receptor internalization; regulation of blood pressure; protein phosphorylation; vasculature development; defense response to Gram-negative bacterium; endothelial cell proliferation; positive regulation of interleukin-8 production; nervous system process involved in regulation of systemic arterial blood pressure; negative regulation of calcium ion transport into cytosol; Вроден имунолошки систем; endothelial cell migration; antifungal humoral response; defense response to Gram-positive bacterium; antimicrobial humoral immune response mediated by antimicrobial peptide; amylin receptor signaling pathway; calcitonin gene-related peptide receptor signaling pathway;
	Извори:Amigo / QuickGO
Ортолози
	796
	12310
	ENSG00000110680
	ENSMUSG00000030669
	P06881
	P70160; Q99JA0
	NM_001033952; NM_001033953; NM_001741; NM_001378949; NM_001378950
	NM_001033954; NM_007587; NM_001289444; NM_001305616
	NP_001029125.1
NP_001029126; NP_001276373; NP_001292545; NP_031613; NP_001029126.1;
	NP_001276373.1
	Википодатоци
Прегл./Уред. човечки	Прегл./Уред. глувчешки

Калцитонин (или тирокалцитонин) е хормон кој се синтетизира од штитната жлезда, поточно од посебни клетки, наречени парафоликуларни клетки. Тој учествува во регулацијата на метаболизмот на калциум и фосфор. Калцитонинот стимулира вградување на калциум во коските и зголемување на концентрацијата на фосфор во крвта. Овој хормон има важна улога и во процесот на окоскувањето.