AFDX-384

AFDX-384 (BIBN-161) е лек кој делува како селективен антагонист на мускаринските ацетилхолински рецептори, со селективност за подтиповите M₂ и M₄. Се користи главно за мапирање на дистрибуцијата на M₂ и M₄мускаринските рецептори во мозокот и проучување на нивната вклученост во развојот и лекувањето на деменција и шизофренија.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Поврзано

Пирензепин (М ₁ селективен антагонист)

Наводи

↑ „M2 receptor binding of the selective antagonist AF-DX 384: possible involvement of the common allosteric site“. Molecular Pharmacology. 53 (2): 304–12. February 1998. doi:10.1124/mol.53.2.304. PMID 9463489.
↑ „A novel muscarinic M(4) receptor antagonist provides further evidence of an autoreceptor role for the muscarinic M(2) receptor sub-type“. European Journal of Pharmacology. 383 (1): 53–6. October 1999. doi:10.1016/S0014-2999(99)00607-X. PMID 10556681.
↑ „Syntheses of R and S isomers of AF-DX 384, a selective antagonist of muscarinic M2 receptors“. Bioorganic & Medicinal Chemistry. 8 (3): 591–600. March 2000. doi:10.1016/S0968-0896(99)00307-7. PMID 10732976.
↑ „Comparative distribution of binding of the muscarinic receptor ligands pirenzepine, AF-DX 384, (R,R)-I-QNB and (R,S)-I-QNB to human brain“. Journal of Chemical Neuroanatomy. 24 (3): 211–23. September 2002. doi:10.1016/S0891-0618(02)00066-2. PMID 12297267.
↑ „M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders“. Brain Research Bulletin. 65 (5): 397–403. May 2005. doi:10.1016/j.brainresbull.2005.02.007. PMID 15833594.
↑ „Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies“. Behavioural Brain Research. 161 (2): 299–305. June 2005. doi:10.1016/j.bbr.2005.02.019. PMID 15922057.
↑ „Decreased muscarinic receptor binding in the frontal cortex of bipolar disorder and major depressive disorder subjects“. Journal of Affective Disorders. 116 (3): 184–91. August 2009. doi:10.1016/j.jad.2008.11.015. PMC 2724602. PMID 19103464.

[pmid9463489-1] „M2 receptor binding of the selective antagonist AF-DX 384: possible involvement of the common allosteric site“. Molecular Pharmacology. 53 (2): 304–12. February 1998. doi:10.1124/mol.53.2.304. PMID 9463489.

[pmid10556681-2] „A novel muscarinic M(4) receptor antagonist provides further evidence of an autoreceptor role for the muscarinic M(2) receptor sub-type“. European Journal of Pharmacology. 383 (1): 53–6. October 1999. doi:10.1016/S0014-2999(99)00607-X. PMID 10556681.

[pmid10732976-3] „Syntheses of R and S isomers of AF-DX 384, a selective antagonist of muscarinic M2 receptors“. Bioorganic & Medicinal Chemistry. 8 (3): 591–600. March 2000. doi:10.1016/S0968-0896(99)00307-7. PMID 10732976.

[pmid12297267-4] „Comparative distribution of binding of the muscarinic receptor ligands pirenzepine, AF-DX 384, (R,R)-I-QNB and (R,S)-I-QNB to human brain“. Journal of Chemical Neuroanatomy. 24 (3): 211–23. September 2002. doi:10.1016/S0891-0618(02)00066-2. PMID 12297267.

[pmid15833594-5] „M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders“. Brain Research Bulletin. 65 (5): 397–403. May 2005. doi:10.1016/j.brainresbull.2005.02.007. PMID 15833594.

[pmid15922057-6] „Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies“. Behavioural Brain Research. 161 (2): 299–305. June 2005. doi:10.1016/j.bbr.2005.02.019. PMID 15922057.

[pmid19103464-7] „Decreased muscarinic receptor binding in the frontal cortex of bipolar disorder and major depressive disorder subjects“. Journal of Affective Disorders. 116 (3): 184–91. August 2009. doi:10.1016/j.jad.2008.11.015. PMC 2724602. PMID 19103464.

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