VGT-309

VGT-309 е експериментална „Катепсин-таргетирана сонда базирана на згасена активност“ дизајнирана да го истакне карциномот во хирургијата со флуоресценција.^[1] ^[2] ^[3]

Наводи

↑ Suurs, Frans V.; Qiu, Si-Qi; Yim, Joshua J.; Schröder, Carolien P.; Timmer-Bosscha, Hetty; Bensen, Eric S.; Santini, John T.; de Vries, Elisabeth G. E.; Bogyo, Matthew (29 September 2020). „Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model“. EJNMMI Research. 10 (1): 111. doi:10.1186/s13550-020-00688-0. ISSN 2191-219X. PMID 32990883.
↑ Santiago, Nicole Lugo; Wen, Wei; Kohut, Adrian; Bensen, Eric; Santini, John; Yim, John; Fong, Yuman; Han, Ernest (1 August 2022). „Preclinical evaluation of a novel cathepsin-activated fluorescent probe VGT-309 for identification of ovarian cancer in a mouse model (248)“. Gynecologic Oncology. 166: S134. doi:10.1016/S0090-8258(22)01471-8. ISSN 0090-8258.
↑ Kennedy, Gregory T.; Holt, David E.; Azari, Feredun S.; Bernstein, Elizabeth; Nadeem, Bilal; Chang, Ashley; Sullivan, Neil T.; Segil, Alix; Desphande, Charuhas (1 September 2022). „A Cathepsin-Targeted Quenched Activity-Based Probe Facilitates Enhanced Detection of Human Tumors during Resection“. Clinical Cancer Research. 28 (17): 3729–3741. doi:10.1158/1078-0432.CCR-22-1215. ISSN 1557-3265. PMC 10257858 Проверете ја вредноста |pmc= (help). PMID 35792882 Проверете ја вредноста |pmid= (help).

[1] Suurs, Frans V.; Qiu, Si-Qi; Yim, Joshua J.; Schröder, Carolien P.; Timmer-Bosscha, Hetty; Bensen, Eric S.; Santini, John T.; de Vries, Elisabeth G. E.; Bogyo, Matthew (29 September 2020). „Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model“. EJNMMI Research. 10 (1): 111. doi:10.1186/s13550-020-00688-0. ISSN 2191-219X. PMID 32990883.

[2] Santiago, Nicole Lugo; Wen, Wei; Kohut, Adrian; Bensen, Eric; Santini, John; Yim, John; Fong, Yuman; Han, Ernest (1 August 2022). „Preclinical evaluation of a novel cathepsin-activated fluorescent probe VGT-309 for identification of ovarian cancer in a mouse model (248)“. Gynecologic Oncology. 166: S134. doi:10.1016/S0090-8258(22)01471-8. ISSN 0090-8258.

[3] Kennedy, Gregory T.; Holt, David E.; Azari, Feredun S.; Bernstein, Elizabeth; Nadeem, Bilal; Chang, Ashley; Sullivan, Neil T.; Segil, Alix; Desphande, Charuhas (1 September 2022). „A Cathepsin-Targeted Quenched Activity-Based Probe Facilitates Enhanced Detection of Human Tumors during Resection“. Clinical Cancer Research. 28 (17): 3729–3741. doi:10.1158/1078-0432.CCR-22-1215. ISSN 1557-3265. PMC 10257858 Проверете ја вредноста |pmc= (help). PMID 35792882 Проверете ја вредноста |pmid= (help).

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