HLA-DR16

Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
главен комплекс на хистокомпатибилност, класа II, DR16
Групи на хаплотипови	DRA01:DRB11601 DRA01:DRB11602
Структура (Види HLA-DR )
Идентификатори	алфа *0101
Симбол(и)	HLA-DRA^{[мртва врска]}^{[мртва врска]}
EBI-^{[ трајна мртва врска ]}HLA	DRA*0101
Идентификатори	бета 1 * 1601 * 1602 * 1604
Симбол(и)	HLA-DRB1^{[мртва врска]}^{[мртва врска]}
EBI-^{[ трајна мртва врска ]}HLA	DRB1*1601
EBI-HLA	DRB1*1602
EBI-HLA	DRB1 * 1604
Споделени податоци
Локус	chr.6 6p21.31

HLA-DR16 (DR16) е HLA - DR серотип кој ги препознава генските производи DRB1*1601, *1602 и *1604. DR16 се наоѓа во Медитеранот на скромни фреквенции. DR16 е дел од постарата HLA-DR2 серотип група која исто така содржи слични HLA-DR15 антигени.

Алели

DR16, DR2 и други серотип препознавање на некои DRB1*16 алели ^[1]
DRB1*	DR16	DR2	DR15	Пример
алел	%	%	%	големина (N)
1601 година	41	29	19	703
1602 година	47	30	16	239
1604 година	> 50			1

Здруженија на болести

DR16 е поврзан со Чага-овата кардиомиопатија,^[2] ревматска срцева болест,^[3] коронарна артериска ектазија,^[4] и хроничен дискоиден лупус еритематозус.^[5]

DRB1*1601 е поврзан со ризик од туберкулоза^[6]

DRB1*1602 : Јувенилен ревматоиден артритис,^[7] ревматска срцева болест,^[3] Церебрален васкулитис Архивирано на 7 август 2007 г.

,^[8] системска склероза (SSc) и анти-ДНК топоизомераза I (анти-топо I) антитела,^[9]^[10] мелиоидоза (Инфекција Burkholderia pseudomallei)^[11]

Проширена врска

Хаплотипот DRB1*1601:DQA1*0102:DQB1*0502 е поврзан со ризик од тубекулоза.^[6]

- *1602:DQA1*0102:DQB1*0502 хаплотип: гробови болест,^[12]^[13] рак на грлото на матката (инфекција со хуман папилома вирус),^[14] склеродерма.^[10]
- *1602:DQA1*05:DQB1*0301 хаплотип: ревматска срцева болест,^[3] системска склероза.^[15]

Генетска поврзаност

DR16 Хаплотипови
Серотипови	DRA	DRB1	DRB5
DR16(2)-DR51	*0101	* 1601 година	*0101
	*0101	*1602	*0101
	*0101	* 1604 година	*0101
	DQA1	DQB1	DRB1
DR16(2)-DQ5 (5.2, 1)	*0102	*0502	* 1601 година
	HLA-A	HLA-B	DRB1
A2-B51(5)-DR16(2)	*0201	*5101	* 1601 година

HLA-DR16 е генетски поврзан со HLA-DR51 и HLA-DQ5 серотиповите.

Наводи

↑ derived from IMGT/HLA
↑ „MHC class I and class II genes in Mexican patients with Chagas disease“. Hum Immunol. 65 (1): 60–5. 2004. doi:10.1016/j.humimm.2003.10.008. PMID 14700597.
↑ ^3,0 ^3,1 ^3,2 „MHC class II alleles in Mexican patients with rheumatic heart disease“. Int J Cardiol. 92 (1): 49–54. 2003. doi:10.1016/S0167-5273(03)00040-8. PMID 14602216.
↑ „HLA-DR B1 and DQ B1 polymorphisms in patients with coronary artery ectasia“. Acta Cardiol. 59 (5): 499–502. 2004. doi:10.2143/AC.59.5.2005222. PMID 15529553.
↑ „Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients“. Clin. Exp. Dermatol. 32 (4): 435–8. 2007. doi:10.1111/j.1365-2230.2007.02391.x. PMID 17376212.
↑ ^6,0 ^6,1 „Frequency of DRB1-DQB1 two-locus haplotypes in tuberculosis: preliminary report“. Tuberculosis (Edinb). 85 (4): 259–67. 2005. doi:10.1016/j.tube.2004.12.003. PMID 15958261.
↑ „HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos“. Hum Immunol. 65 (4): 359–65. 2004. doi:10.1016/j.humimm.2004.01.016. PMID 15120191.
↑ „Association of HLA-DRB1*1602 and DRB1*1001 with in Colombian mestizos as markers of Amerindian ancestry“. Int J Cardiol. 75 (Suppl 1): S113–6. 2000. doi:10.1016/s0167-5273(00)00181-9. PMID 10980348.
↑ „Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody“. Arthritis Rheum. 42 (3): 465–74. 1999. doi:10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y. PMID 10088769.
↑ ^10,0 ^10,1 „HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis)“. Tissue Antigens. 53 (1): 74–80. 1999. doi:10.1034/j.1399-0039.1999.530108.x. PMID 10082433.
↑ „HLA-DR and -DQ associations with melioidosis“. Hum Immunol. 59 (9): 580–6. 1998. doi:10.1016/S0198-8859(98)00052-4. PMID 9757914.
↑ „The association between HLA class II haplotype with Graves' disease in Thai population“. Tissue Antigens. 67 (1): 79–83. 2006. doi:10.1111/j.1399-0039.2005.00498.x. PMID 16451208.
↑ „Association of HLA-DR and -DQ genes with Graves disease in Koreans“. Hum Immunol. 66 (6): 741–7. 2005. doi:10.1016/j.humimm.2005.03.001. PMID 15993720.
↑ „HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women“. Hum Immunol. 64 (9): 890–5. 2003. doi:10.1016/S0198-8859(03)00163-0. PMID 12941545.
↑ „Increased prevalence of systemic sclerosis in a Native American tribe in Oklahoma. Association with an Amerindian HLA haplotype“. Arthritis Rheum. 39 (8): 1362–70. 1996. doi:10.1002/art.1780390814. PMID 8702445.

[1] rived from IMGT/HLA

[2] „MHC class I and class II genes in Mexican patients with Chagas disease“. Hum Immunol. 65 (1): 60–5. 2004. doi:10.1016/j.humimm.2003.10.008. PMID 14700597.

[rhd-3] 3,0 ^3,1 ^3,2 „MHC class II alleles in Mexican patients with rheumatic heart disease“. Int J Cardiol. 92 (1): 49–54. 2003. doi:10.1016/S0167-5273(03)00040-8. PMID 14602216.

[4] „HLA-DR B1 and DQ B1 polymorphisms in patients with coronary artery ectasia“. Acta Cardiol. 59 (5): 499–502. 2004. doi:10.2143/AC.59.5.2005222. PMID 15529553.

[pmid17376212-5] „Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients“. Clin. Exp. Dermatol. 32 (4): 435–8. 2007. doi:10.1111/j.1365-2230.2007.02391.x. PMID 17376212.

[1601_TB-6] 6,0 ^6,1 „Frequency of DRB1-DQB1 two-locus haplotypes in tuberculosis: preliminary report“. Tuberculosis (Edinb). 85 (4): 259–67. 2005. doi:10.1016/j.tube.2004.12.003. PMID 15958261.

[JRA_ColMez-7] „HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos“. Hum Immunol. 65 (4): 359–65. 2004. doi:10.1016/j.humimm.2004.01.016. PMID 15120191.

[arteritis-8] „Association of HLA-DRB1*1602 and DRB1*1001 with in Colombian mestizos as markers of Amerindian ancestry“. Int J Cardiol. 75 (Suppl 1): S113–6. 2000. doi:10.1016/s0167-5273(00)00181-9. PMID 10980348.

[ATI-9] „Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody“. Arthritis Rheum. 42 (3): 465–74. 1999. doi:10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y. PMID 10088769.

[Tan_F,_Stivers_D,_Arnett_F,_Chakraborty_R,_Howard_R,_Reveille_J_1999_74–80-10] 10,0 ^10,1 „HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis)“. Tissue Antigens. 53 (1): 74–80. 1999. doi:10.1034/j.1399-0039.1999.530108.x. PMID 10082433.

[11] „HLA-DR and -DQ associations with melioidosis“. Hum Immunol. 59 (9): 580–6. 1998. doi:10.1016/S0198-8859(98)00052-4. PMID 9757914.

[GD_thai-12] „The association between HLA class II haplotype with Graves' disease in Thai population“. Tissue Antigens. 67 (1): 79–83. 2006. doi:10.1111/j.1399-0039.2005.00498.x. PMID 16451208.

[13] „Association of HLA-DR and -DQ genes with Graves disease in Koreans“. Hum Immunol. 66 (6): 741–7. 2005. doi:10.1016/j.humimm.2005.03.001. PMID 15993720.

[14] „HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women“. Hum Immunol. 64 (9): 890–5. 2003. doi:10.1016/S0198-8859(03)00163-0. PMID 12941545.

[15] „Increased prevalence of systemic sclerosis in a Native American tribe in Oklahoma. Association with an Amerindian HLA haplotype“. Arthritis Rheum. 39 (8): 1362–70. 1996. doi:10.1002/art.1780390814. PMID 8702445.

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