'''Амилоид бета''' ('''Aβ''' orили '''Abeta''') претставуваат [[пептид]]и изградени од 36–43 [[аминокиселини]] кои се главна компонента на [[амилоидните плаки]] во мозокот кај луѓето со [[Алцхајмерова болест]].<ref name="pmid22813427">{{cite journal | vauthors = Hamley IW | title = The Amyloid Beta Peptide: A Chemist's Perspective. Role in Alzheimer's and Fibrillization | journal = Chemical Reviews | volume = 112 | issue = 10 | pages = 5147–92 | date = October 2012 | pmid = 22813427 | doi = 10.1021/cr3000994 | url = http://centaur.reading.ac.uk/30230/2/AbetaRevisednew%20-IWH%20%281%29.pdf }}</ref> Овие пептиди се добиваат од [[амилод прекурсорен протеин]] (APP), под дејство на ензимите [[Бета-секретаза 1|бета секретаза]] и [[гама секретаза]]. Aβ moleculesмолекулите canможе aggregateда toагрегираат formи flexibleда solubleформираат [[oligomer]]sфлексибилни which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to aрастворливи [[prionолигомер]]и infection.кои Theможе oligomersда areпостојат toxicво toнеколку [[nerve cell]]sформи.<ref>{{cite journal | vauthors = Haass C, Selkoe DJ | title = Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide | journal = Nature Reviews. Molecular Cell Biology | volume = 8 | issue = 2 | pages = 101–12 | date = February 2007 | pmid = 17245412 | doi = 10.1038/nrm2101 | s2cid = 32991755 }}</ref> The other protein implicated in Alzheimer's disease, [[tau protein]], also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.<ref>{{cite journal | vauthors = Nussbaum JM, Seward ME, Bloom GS | title = Alzheimer disease: a tale of two prions | journal = Prion | volume = 7 | issue = 1 | pages = 14–9 | date = Jan–Feb 2013 | pmid = 22965142 | pmc = 3609044 | doi = 10.4161/pri.22118 }}</ref><ref>{{cite journal | vauthors = Pulawski W, Ghoshdastider U, Andrisano V, Filipek S | title = Ubiquitous amyloids | journal = Applied Biochemistry and Biotechnology | volume = 166 | issue = 7 | pages = 1626–43 | date = April 2012 | pmid = 22350870 | pmc = 3324686 | doi = 10.1007/s12010-012-9549-3 }}</ref>
